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pentobarbital will minimize the level or impact of lefamulin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Steer clear of coadministration of lefamulin with strong or moderate CYP3A inducers Except the gain outweighs hazards. Observe for reduced efficacy.pentobarbital will lower the extent or effect of alo